Summaries by Inventor Wang, Lihong
An, Woo Jin ; Wang, Lihong
T-010123
— Background: Optical imaging through a highly scattering medium, such as biological tissue, has been stymied by the loss of optical focusing inside such a medium. Current optical imaging techniques, such as optical coherence tomography, image up to approximately one optical transport mean free path…
Compressed-sensing Ultrafast Photography (CUP)Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733
— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…
Photoacoustic tomography of human brainAnastasio, Mark ; Cai, Xin ; Maslov, Konstantin ; Nie, Liming ; Wang, Lihong
T-013043
— This technology features a photon recycler to increase light transmittance through the human skull, a subtraction imaging method to image targets through human skull, and a filtering method to improve the contrast. Optical imaging is desirable because high functional hemoglobin contrast can be dire…
Scanning Apparatus for Reflection-Mode Photoacoustic TomographyMaslov, Konstantin ; Wang, Lihong
T-007645
— The greatest limitation on clinical use of existing photo-acoustic imaging technologies is the slow scanning speed caused by mechanical scanning, the bulky design of the scanning apparatus, and the necessity to immerse the body part into a ultrasonic coupling liquid. The present invention overcomes…
Optical Resolution Photoacoustic Imaging Device for Port-Wine StainsMaslov, Konstantin ; Rao, Bin ; Wang, Lihong
T-012585
— A photoacoustic tomography device that provides high optical absorption contrast with high lateral resolution, including very good melanin distribution images, for port wine stain birthmarks.
Photon tunnelingAn, Woo Jin ; Wang, Lihong
T-012515
— Photon tunneling has the potential to guide light to the core of a human body in vivo. Imaging, sensing, and therapy are among the applications for this technology. Light, as opposed to potentially harmful x-rays, is an ideal non-ionizing radiation for imaging and treating biological tissue, however…
Compressed-sensing Ultrafast Photography (CUP)Gao, Liang ; Liang, Jinyang ; Wang, Lihong
T-014733
— Compressed-sensing ultrafast photography (CUP) is an ultrafast imaging technique that can capture non-repetitive, time-evolving events at up to 100 billion frames per second. Compared to existing ultrafast imaging methods, CUP has a prominent advantage in measuring an x, y, t (x, y, spatial coordina…
Reversibly switchable photoacoustic tomography using a bacterial phytochrome as a genetically encoded near-infrared photochromic probeLi, Lei ; Wang, Lihong ; Yao, Junjie
T-015670
— The invention is a novel photoacoustic imaging technique, termed reversibly switchable photoacoustic tomography (RS-PAT). It exhibits a large penetration depth, a high detection sensitivity, and a spatial super-resolution. The most important feature of this technique is that it significantly incre…
Grueneisen-memory photoacoustic microscopyWang, Lidai ; Wang, Lihong ; Zhang, Chi
T-014165
— Lihong Wang, Professor at Washington University in St. Louis, is a pioneer in the field of Photoacoustic (PA) Imaging. His innovations have enabled non-invasive imaging of living organisms at scales ranging from subcellular to whole-body at depths and resolutions that are simply impossible with any …
Optical Coherence Computed TomographyLi, Li ; Wang, Lihong
T-008832
— Optical coherence tomography (OCT) utilizes optical light to obtain an image of opaque or translucent objects, ie tissue. Because scattered light contributes to the bluring found in other optical imaging techniques, OCT filters out all the scattered light. An image is formed using only the back refl…
Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detectionMaslov, Konstantin ; Rao, Bin ; Song, Liang ; Wang, Lihong
T-010922
— In clinical practice, high imaging speed is critical to reduce motion artifacts, cost, and patient discomfort. Researchers at Washington University have developed multi-focal optical-resolution photoacoustic microscopy (MFOR-PAM) capable of high-resolution imaging of hemoglobin concentration and oxy…
“Gemini” connector device to prevent peripheral venous catheters from dislodging and leakingArias, Eric ; Bayly, Philip ; Dacey, Ralph ; Derdeyn, Colin ; Genin, Guy ; Kim, Albert ; Leuthardt, Eric ; Norlin, James ; Scheid, Brittany ; Singamaneni, Srikanth ; Vemuri, Chandu ; Wang, Lihong ; Zipfel, Gregory
T-014841
— Technology Description A team of researchers at Washington University in St. Louis have developed the patented “Gemini” breakaway connector to turn peripheral venous catheter (PVC) fluid flow on and off without leaking. In addition, this easy-to-use device is designed to prevent PVC di…
High resolution imaging using subwavelength grating structuresShen, Jung-Tsung ; Shen, Yuecheng ; Wang, Lihong
T-012856
— Conventional optics are generally restrained by a law of physics known as the diffraction limit, which dictates that optical systems can only resolve images down to about half the wavelength of the light used to produce the image (λ/2), or down to about 200 nanometers for most standard optics…
Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data (combined with 013043)Anastasio, Mark ; Huang, Chao ; Nie, Liming ; Schoonover, Robert ; Wang, Lihong
T-013450
— Existing high-resolution human brain imaging modalities such as X-ray computed tomography (CT) and magnetic resonance imaging (MRI) are expensive and employ bulky and generally non-portable imaging equipment. Moreover, X-ray CT is unsafe for patients who need long time monitoring of brain diseases …
